Stilbenoids activity

Hernandez-Romero Y Rojas J-I, Castillo R, Rojas A, MataR, Spasmolytic effects, mode of action, and structure-activity relationships of stilbenoids from Nidema boothii, J Nat Prod 67 160—167, 2004. 

The anti-virus activity research concerning stilbenoids mainly focuses on HIV. Glepidotin D (162) was isolated from the leaves of Glycyrrhiza lepidota as the compound responsible for the anti-viral activity with an EC50 of 2.0 g/ml and an ICso of 5.0 //g/ml, which excludes the need for further study [98]. 

Most stilbenoids possess antioxidant activities because they possess polyphenol functions in the molecules. Some of their beneficial effects, hepatoprotective action, cardiovascular protection, for instance, are in close relation to their antioxidant activities. Several models have been employed in the assay such as lipid peroxidation system, human low-density lipoprotein model, xanthine oxidase system and l,l-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging model, which is the most commonly used protocol. 

Some stilbenoids from the roots of Vitis thunbergii, such as vitisinols B, C, D (772, 773, 576), (+)-e-viniferin (445), (-)-viniferal (771), ampelopsin C and (+)-vitisin C (700), displayed strong free radicalscavenging activities (ICsos 2.8 to 6.6 //M) [245]. The antioxidant capacity of tra s-e-viniferin (445) has also been evaluated and compared with those of resveratrol (1) and s)mthetic stilhene derivatives [504]. 

The plant-insect chemical interactions concerning the stilbenoids have just been reviewed [509] (-i-)-Ampelopsin B (806) and ct-viniferin (635) antagonized the action of 20-hydroxyecdysone [510] cw-miyabenol A (735), kobophenol B and cw-miyabenol C (663) showed competitive binding to ecdysteroid receptors [337] resveratrol (1) and oligomers (suffruticosols A-C, 589-591) also exhibited ecdysteroid antagonistic activity [297]. 

The antioxidant activity of resveratrol (Fig. 5), a stilbenoid derivative, has been reported [130]. 

Waffo-Teguo, P., Hawthorne, M.E., Cuendet, M., Merillon, J.M., Kinghom, A.D., Pezzuto, J.M., and Mehta, R.G., Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifem) cell cultures, Nutr. Cancer, 40 (2), 173-179,2001. 

Many stilbene derivates (stilbenoids) are naturally present in plants. The most widely distributed stilbenoids are resveratrol, combretastatins, and pterostilbene. These agents are derived from terrestrial plants, microorganisms, marine organisms, and animals [1,2]. This chapter is a brief review on diverse biological activities of stilbenes in cells, organs, and animals. 

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