Steroids micellar partition coefficients

Table 10 Micellar partition coefficients of some steroids in Brij 35...

The micelle/water partition coefficient for many solutes have been shown to correlate to the octanol/ water partition coefficientJ ° Data in Table 8, from Azaz and Donbrow, show that the micellar partition coefficients of the methylphenols increase with the number of methyl groups. Collett and Tobin showed that the micellar partition coefficients of several benzoic acid derivatives are proportional to their octanol-water partition coefficient for poloxamers (Table 9). Tomida et al. also illustrated that most of the 34 monosubstituted benzoic acids with Brij 35 have micellar partition coefficients that are inversely proportional to their aqueous solubilities and proportional to their octanol-water partition coefficients. The data of Tomida, Yotsuyanagi, and Ikeda[ °l for some steroid hormones (Table 10), further illustrate the parallelism between octanol-water and micelle-water partition coefficients. 

Table 6.20 Partition coefficients of steroids between water and ether, P, and aqueous and micellar phases from solubility, P, and dialysis, P, at 25° C...

Probably more work has been carried out on steroid solubilization than on most other classes of drug. In spite of the mass of data the behaviour of some steroid-surfactant systems, especially those containing two steroids, is by no means understood. The use of oil-water partition coefficients allows us to predict with a reasonable degree of precision the rank order solubility of a given steroid of a series in a surfactant, but not yet to relate surfactant properties to micellar capacity. 

---

See also in sourсe #XX -- [ ]

---