Steroidal alkaloids teratogenic potencies

Steroidal alkaloids found in Veratrum spp. and Solanum spp. with their relative teratogenic potency, as determined in a hamster bioassay. 

Table 2. Relative Teratogenic Potencies of Steroidal Alkaloids...

Appendix) is graphically emphasized in Fig. (11) with values of the relative teratogenic potency of individual steroidal alkaloids from Table 2 placed adjacent to their structural type. The variance in values for the jervanes, solanidanes, and spirosolanes primarily reflects the level of saturation at C-5, C-6 e.g., 100 vs. 40 for jervanes, 32 vs. 9 for solanidanes, and 6 vs. 4 for spirosolanes. In each instance the higher value... 

RELATIVE TERATOGENIC POTENCIES OF STEROIDAL ALKALOIDS Fig. (11). Correlation of relative teratogenic potencies (from Table 2) with steroidal alkaloid structure. For example, values for jervine (100), dihydrojervine (65), cyclopamine (47), and tetrahydrojervine (40) are shown adjacent to the tetrahydrojervine structure that represent jervanes, in general. 

Structures of the steroidal alkaloids whose relative teratogenic potencies are listed in Table 2 and whose embryolethality and teratogenicity is recorded in Table 3 are provided as follows jervine (1), cyclopamine (2), tomatidine (4), and solasodine (6) are listed in the text. Structures for 22/ , 255-solanidine, a-solanine, and ct-chaconine are provided in Fig. (10). In solanidine-N-oxide, the electron pair on the nitrogen atom of solanidine in Fig. (10) is replaced by an oxygen atom. Dihydrosolanidine refers to solanidine with a reduced C-5, C-6 linkage. Dihydrojervine refers to the jervine structure (1) with the C-12, C-13 bond saturated and tetrahydrojervine has both C-5, C-6 and C-12, C-13 linkages saturated. Dihydrosolasodine is shown as structure 6 having C-5, C-6 saturated. 

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