Steroid hormones receptors for

Steroid hormone receptors (for gonadal steroids and adrenocortical steroids) are complex proteins inside the target cell. The steroid penetrates, is bound and translocates into the cell nucleus, which is the principal site of action and where RNA/protein synthesis occurs. Compounds that occupy the receptor without causing translocation into the nucleus or the replenishment of receptors act as antagonists, e.g. spironolactone to aldosterone, cyproterone to androgens, clomiphene to oestrogens. 

Eissa, S., Khalifa, A., el-Gharib, A., Salah, N., and Mohamed, N. K. (1997) Multivariate analysis of DNA ploidy, p53, c-erbB-2 proteins, EGFR, and steroid hormone receptors for prediction of poor short term prognosis in breast cancer. Anticancer Res. 17, 1417-1423. 

These mclude the steroid hormone receptors for predicting response... 

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