Sterilisation methods selecting

EMEA/CVMP/065/99 final Decision trees for the selection of sterilisation methods (February 2000)... 

The European agency for the evaluation of medicinal products. In Decision Trees for the Selection of Sterilisation Methods London, 1998. 

From here on this chapter expands the properties of various plastics, the means by which certain physical and chemical characteristics can be identified and quantified, together with the constituents which may be found in a plastic. The converting processes may contribute other factors relevant to the selection and clearance of a plastic pack. The chapter concludes by reference to sterilisation methods and references. (The next chapter places particular emphasis on the clearance of a plastic pack , and should be read in conjunction with this section.)... 

Biological indicators, (i.e., preparations of bacterial cultures, usually spores of selected resistant strains) are much less reliable than physical monitoring methods (except in ethylene oxide sterilisation). 

Ion-selective electrodes have a role for monitoring milk both for its calcium content and as a possible vehicle for health fluoridation programmes. The ion-selective electrode method appears to give higher ionic calcium levels (< 2.71 mmol dm" ) than the method of EDTA titration of ion-exchange eluates ( 2.52 mmol dm ) possibly because of the smaller pH changes in the former case. However, in passing from raw milk to sterilised milk ( 2.27 mmol dm ) and pasteurised milk ( 2.04 mmol dm" ) there is a fall in the ionic calcium level [275]. 

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