Steric effects in heteroaromatics

Gallo, R. J., Roussel, C., Berg, U., The Quantitative Analysis of Steric Effects in Heteroaromatics, 43, 173. 

Understanding, rationalizing, and predicting both reactivity and the energetics of dynamic stereochemistry are of major importance in heterocyclic chemistry and one or both of these topics are a concern of the majority of the contributions in Advances in Heterocyclic Chemistry. No previous systematic study has been reported which treats quantitatively steric effects in heteroaromatics this is the purpose of this article. 

The reason for writing this article is that important progress in the quantitative analysis of steric effects in heteroaromatics has been made recently by linear free energy relationships (LFER), geometrical, and theoretical methods. Also, heterocycles have been used to propose and exemplify new concepts and new parameters in physical organic chemistry. 

---