Structure Searching Stereospecific

The strategy adopted for attacking this problem is, so to speak, an orthodox one. This can be divided into five distinct steps first, search for catalyst having a high degree of stereospecificity second, isolation and purification of the catalyst third, determination of structure and clarification of the chemical behavior of the catalyst fourth, elucidation of the mode of action of the catalyst on the monomer fifth, clarification of catalytic behavior in the polymerization reaction of the catalyst and its derivatives. 

Further investigations showed that the means of improving enantioselectivity consists not in searches for new modifier structures but in elaboration of the stereochemical mechanism of reaction based on concepts of dual sites, the existence of chiral modified and non-stereospecific centers, on the surface of catalysts (see, Sachtlei , Klabunovskii Smith - )... 

CAS has undertaken a multi-year effort to renovate the Registry System. As part of this effort, we are currently engaged in adding atom/bond specific stereodescriptors to the connection tables of stereospecific substances already on the Registry File. These extensions will, in turn, permit us to enhance structure display and substructure search to use accurately the stereochemical information available. 

---