Stereoselectivity in Other Amino Acid Catalyzed Reactions

Stereoselectivity in Other Amino Acid Catalyzed Reactions 

Houk and coworker have examined the stereoselectivily in a series of amino acids in an intramolecular aldol reaction using the DFT(B3LYP) computational tool [51]. They attributed increased conformational flexibility in the stereoselective bond forming transition state as the origin of the lower enantiomeric excess noted with acyclic primary amino acids. Himo, Cordova, and coworkers have used density functional theory computations to examine the stereocontroUing transition states for the (S)-alanine catalyzed intermolecular aldol reaction between cyclohexanone and para-nitrobenzaldehyde [52]. In a very recent study, Houk, Mahrwald, and coworkers compared the transition states of an asymmetric aldol reaction 

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