Stereoselective Synthesis of 1,3-Diols Asymmetric Reductions

SCHEME 2.129 Lewis base activation using chiral bisphosphoramide 34. 

These building blocks have been used by enzymatical and chemical strategies to establish chiral centers and, in the case of VMAR, to build reductively on the existing secondary alcohol in order to produce stereoselectively 1,3-diols. 

3 Chemical Reductions Enantioselective reduction of unsymmetric ketones to optically active alcohols is very important in organic synthesis. In the foreword to this section, we will summarize the best practical and useful methods and reagents. 

BINAL-H (Noyori) Noyori has devised a chiral hydride reagent and its enantiomer by the modification of lithium aluminum hydride with equimolar amounts of either 

OH O O Vinylogous aldol product generated with the aid of Chan s diene 

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