Stereoisogram approach promolecules

Let us examine promolecules of Types I, IH, and V to show a systematic rationaU-zatimi provided by the stereoisogram approach (Table 10.2), where the concept of cMrality-faitlrfulness (Fujita 2009d) assures a systematic but subsidiary linkage between chirality and /tS-stereogenicity, which are independent concepts to each other. 

In the stereoisogram approach, prochirality of a geometric meaning is characterized by means of a single criterion based on the term enantiotopic (Table 10.5), where such prochirahty emerges in conversions of achiral promolecules into chiral ones, i.e.. Type IV —> I, Type IV —> II, and Type V —> III. 

The stereoisogram approach (Table 10.5) is capable of detecting a coincident appearance of an enantiotopic case and an / 5-diastereotopic case (Figs. 10.7 and 10.13) as well as a coexistence of an enantiotopic case (e.g.. Figs 10.14a and 10.15) and an f S -diastereotopic case (e.g.. Figs. 10.14a and b) in a promolecule (46). The conventional approach (Table 10.6) is completely helpless to detect such interrelations between prochirahty and pro-/ 5-stereogenicity. 

---