Stereochemistry basic concepts

M. Nogradi, Stereochemistry Basic Concepts and Applications. Pergamon Press, Oxford, 1981. 

M. Nogradi, Stereochemistry. Basic Concepts and ApplieationSy Akad4mlai Kiado, Bud2q>est 1981. 

Nogradi M (1981) Stereochemistry, basic concepts and applications. Akademia Kiado, Budapest... 

The basic concepts of stereochemistry were independently developed by varft Hoff and Le Bel in 1874. Based on their findings Emil Fischer suggested that biological macromolecules are composed of chiral l amino acids and d sugars and in 1894 proposed his famous key and lock hypothesis that two chiral molecules interact through shape complementarity with each other and are therefore stereospecific [15]. 

The stereochemistry of pyridoxal phosphate-catalyzed reactions was last summarized comprehensively in 1971 by Dunathan [2], who outlined many of the basic concepts in this field. Aspects of PLP catalysis have been discussed in other reviews on enzyme reaction stereochemistry (e.g., [9]), and a brief review, emphasizing their own work, has recently been published by the present authors [ 10]. Much work has been done in this field during the past ten years, most of it supporting the concepts laid out in Dunathan s review, often refining the picture and sometimes modifying the original ideas. 

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