Stereochemical concepts of pyridoxal phosphate catalysis

The stereochemistry of pyridoxal phosphate-catalyzed reactions was last summarized comprehensively in 1971 by Dunathan [2], who outlined many of the basic concepts in this field. Aspects of PLP catalysis have been discussed in other reviews on enzyme reaction stereochemistry (e.g., [9]), and a brief review, emphasizing their own work, has recently been published by the present authors [ 10]. Much work has been done in this field during the past ten years, most of it supporting the concepts laid out in Dunathan s review, often refining the picture and sometimes modifying the original ideas. 

Finally, yet another concept, dealing with the spacial orientation of the cofactor in the protein, was developed by Ivanov and Karpeisky. These authors reasoned that the plane of the cofactor must rotate relative to the protein and the noncovalently bound substrate during the transition from the coenzyme-lysine Schiff s base to the 

In the following discussion of more recent results on the stereochemistry of PLP enzyme reactions, some of the newer data will be analyzed in terms of these early concepts. 

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