Stenosolen heterophyllus

The structure of ervafoline (314), one of the eight bisindole alkaloids from the leaves of Stenosolen heterophyllus, was elucidated earlier by the 3f-ray method. A detailed 400 MHz H n.m.r study of three of the other seven bisindole alkaloids has allowed the structures of 19 -hydroxyervafoline (315), ervafolene (316), and 19 -hydroxyervafolene (317) to be elucidated,u7d from which it appears that ervafoline and 19 -hydroxyervafoline are the 14, 15 -/ -epoxides of ervafolene and 19 -hydroxyervafolene.11 ld... 

The recent reports of the occurrences of these alkaloids are given in Table II. Pandoline (657) has been isolated from the leaves and stems of Melodinus polyadenus (Baill.) Boiteau 99, 373), from Ervatamia obtusius-cula Mgf. (373), and from the leaves of E. lifuana Boiteau 374), Tabemae-montana citrifolia L. 32), Stenosolen heterophyllus (Vahl) Mgf. 29, 375), and E. orientalis (R. Brown) Domin 374). 20-Epipandoline (658) occurs in the first four of these species, and pandine ( 9) in the last four, and also in the stems and leaves of Tabernaemontana pandacaqui Poir 376). 

Peschiera buchtieni Peschiera van heurckii Stenosolen heterophyllus Tabemaemontana fuchsiaefolia Tabemaemontana heterophylla... 

The leaves of Stenosolen heterophyllus (Vahl) Mgf. (family Apocynaceae), from French Guyana, contain seven dimeric alkaloids, of which ervafoline is identical with the alkaloid previously isolated" by Levy and his collaborators from Ervatamia pandacaqui. The structure of ervafoline (276), elucidated by the X-ray method, is novel, and contains an aspidospermidine unit attached to a pandoline component via three bonds, namely to C-3, C-16 to C-21, and C-2 ... 

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