Stearoyl-glycolyl chloride

Alternative (Bl 3.6 grams (0,01 mol) prednisolone and 4.32 grams (0.012 mol) stearoyl-glycolyl-chloride, separately dissolved in dry dioxane, are added with 0.B9 ml (0.011 mol) dry pyridine. The mixture is kept at 60°C for 20 hours, then poured into water-ice and filtered. Crystallization from diluted ethanol results in prednisolone-21-stearoyl-glycolate (MP 104°-105°C). 

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