Steady state kinetics of reversible effectors and ionic equilibria

4 Steady state kinetics of reversible effectors and ionic equilibria Practical reasons for studying inhibitors 

As noted in a number of sections of this volume, the nomenclature of enzymology has been adopted for the description of reactions of receptors in general. Competitive, non-competitive and uncompetitive inhibitors are classified in terms of their effects on the Michaelis parameters and 

Comparing this equation with equation (3.3.11) (where is substituted for cai E) one can write 

The other Michaelis parameter, F,nax cat E(0) not affected by a competitive inhibitor. The clear distinction of competitive inhibition from any other is that, on substrate saturation, the resulting maximum velocity is always the same, regardless of inhibitor concentration. 

In contrast to the above scheme for competitive inhibition, non-competitive inhibition affects both and and cannot be compensated for by 

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