Staudinger ligation strategy

Koehn, M., Wacker, R., Peters, C., Schroeder, H., Soulere, L., Breinbauer, R., Neimeyer, C. M., Waldmann, H. Staudinger ligation A new immobilization strategy for the preparation of small-molecule arrays. Angew. Chem., Int. Ed. Engl. 2003, 42, 5830-5834. 

Kohn M, Wacker R, Peters C, Schroder H, Soulere L, Breinbauer R, Niemeyer C, Waldmann H. Staudinger ligation a new immobilization strategy for the preparation of smaU-molecule arrays. Angew Chem Int Ed 2003 42 5830-5834. 

Hackenberger and Kleineweischede reported a traceless Staudinger ligation for the head-to-tail macrocyclization of peptides without a deprotection step (Fig. 8) [63]. In this strategy, a phosphine tethered to a thioester at the C-terminus of a peptide reacts intramolecularly with an azide at the N-terminus to form the cyclic peptide. 

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