Status, antioxidant thiamin

Another important question relates to the selective sensitivity of specific brain areas to thiamine deficiency. The basis for this has been discussed in terms of differences in regional metabolism, antioxidant status, or differences in thiamine turnover, but without actual data (Desjardins and Butterworth, 2005). Similar regional sensitivity has been seen with bilirubin and copper deposition/damage without explanation. Much remains to be learned. 

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