Statine biological activity

Weibel, E.K., Hadvary, P., Hochuli, E., Kupfer, E. and Lengsfeld, H. (1987) Lip-statin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. J. Antibiotics 40, 1081-1085. 

Statine (4-amino-3-hydroxy-6-methylheptanoic acid, 6.95) is an important hydroxy amino acid with biological activities that have attracted considerable OH... 

HomoallyUc amines are useful intermediates in the synthesis of biologically active compounds such as statin, conine, lobeline, sedamine, SKF-1(K)330-A, epothilone, p-lactams, p-amino acids, and many natural products. The synthesis of those interesting precursors is also possible starting from an imine instead of a carbonyl compound, through this kind of reactivity, known in this case as aza-Sakurai reaction [94, 95]. Its multicomponent version involves the in situ formation of that imine, and few recent examples are shown here. 

Biological target Menthol is a natural terpenoid with agonist activity at the thermoreceptive, non-selective cation channel, transient receptor potential mela-statin type 8 (TRPM8). Present on nerve fibres and skin cells, these channels are activated by a fall in temperature and mediate analgesia. Menthol is also an agonist at GABAa receptors, for which (+)-menthol reveals stereoselectivity. 

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