Startle circuit

Davis M, Gendelman DS, Tischler MD, Gendelman PM. Aprimary acoustic startle circuit lesion and stimulation studies. J Neurosci 1982 2 791-805. 

I ask them to say a few words about how they got started. The students assume that they started in their present profession and knew all along that it was what they wanted to do. Luckily for me, most of them got into their field by a circuitous route, to their surprise, after many detours. The students are startled. They can hardly conceive of a career that was not pre-planned. They can hardly imagine allowing the hand of God or chance to nudge them down some unforeseen trail. 

With the application and development of concepts of electronic circuit and systems theory, and techniques from multivariate statistics, we obtain a MDS correlation metric diagram that defines and represents the putative (not necessarily causal) connections given by the correlations, and the strength of kinetic interactions among the species of a reaction network from a time-series determination of chemical concentrations. In addition, we obtain the startling result that, for the systems studied, the MDS diagram recapitulates many features of the reaction mechanism. 

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