Staphylococcus aureus sputum cultures

A 76-year-old woman with previous exposure to isoflurane 3 years earlier underwent an above-knee amputation for a liposarcoma using isoflurane anesthesia. On day 3 postoperatively she became febrile and confused. Bacterial cultures later showed Staphylococcus aureus in the sputum and Escherichia coli in the urine. Associated hypotension for 2 hours resolved with inotropic support and here renal function remained normal. On day 6 she became jaundiced and developed further hypotension. Despite intensive care treatment she died on day 7. An autopsy showed centrilobular necrosis consistent with drug-induced hepatitis. All liver serology was negative. 

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