Stannanes polymer-supported

Some interesting procedures are being developed to make the present protocol more useful as a synthetic tool. Directing to the combinatorial synthesis, solid-phase syntheses have currently been under development using polymer-supported stannanes (Scheme 69) [263-268] or electrophiles (Scheme 70, Scheme 71) [149, 269-272]. In the latter case, unreacted organotin reagent as... 

Stannane based Hnkers (Tab. 3.8) are used for the StiUe reaction (see below, section 3.3.2.1) onsoHd supports [119]. Nicolaouetal. developed polymer-bound aUcenylstan-nanes to obtain the natural product (S)-zearalenone by an intramolecular StiUe reaction and a cyclative cleavage [120]. 

Since the renaissance of solid-phase organic chemistry in 1992, carbon-carbon bond formation reactions on solid support have probably been the best studied reactions. Many different facets of the Suzuki, Heck and Stille reactions have been evaluated. The influence of linkers, catalyst, solvents, microwave, polymer-bound aryl halides or polymer-bound arylboronic acids (or stannanes) have been studied in detail. 

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