Standards Cont

ASTM Specifications (Cont d) ASTM Specifications (Cont d) GTI Standard... 

NATIONAL (cont.) Treatment standards for hazardous debris Yes 40 CFR 268.45 EPA 1992a... 

TABLE 6 B73 STANDARDIZED ELECTRONIC DATA EXCHANGE FILE SPECIFICATION (CONT D)... 

Special acknowledgement was made by the Committee to Mrs W. Bonny, Dr S. Kopp, Mrs A.N. Lo Conte, Ms M.-L. Rabouhans, Dr L, Rago, and Dr P. Vanbel, Quality Assurance and Safety Medicines, Department of Medicines Policy and Standards, WHO, Geneva, Switzerland, who were instrumental in the preparation and proceedings of the meeting. 

Table 3.1 (cont.) Properties of gases at standard temperature and pressure (273°K, 1 atm)... 

Table 16.2., cont. Biodiesel Standards ASTM D6751 and EN 14214... 

Fig. 6. Water at protein-protein interfaces. Four protein-protein complexes are shown with one component in front of the other and the protein backbones drawn as a tube. The gray surface belongs to the back protein and is in contact with the front protein. Red spheres represent interface water molecules. The chymotrypsin-ovomu-coid (Icho) complex has a dry protease—inhibitor interface. The interface between the Fv fragments of antibodies D1.3 and E5.2 is a wet antibody—antigen complex (Idvf). These two interfaces are standard size, whereas the P-lactamase-BLIP inhibitor interface and the Ga-Gp interface of transducin (Igot) are large interfaces. Figure taken from Lo Conte et al. (1999) and drawn with GRASP (see Web Sites).

The histogram of the interface areas observed in a sample of 75 protein-protein complexes analyzed by Lo Conte etal. (1999) is shown in Fig. 8. In this sample, the majority of the complexes (70%) have interfaces in the range 1200-2000 A. This range includes 19 of 24 protease-inhibitor complexes, 18 of 19 antigen-antibody complexes, and 15 of 32 other types of protein-protein complexes in the sample analyzed by Lo Conte etal. (1999), who define a standard size interface as having = 1600 400 A. General characteristics of such interfaces are listed in Table IV two typical examples are shown in Fig. 6 the chymotrypsin-ovomucoid inhibitor and the FvD1.3-Fv E5.2 interfaces. A standard size interface... 

Fig. 8. Histogram of interface areas in protein-protein complexes. The sample of 75 interfaces in protein-protein complexes (Lo Conte et al., 1999) includes 24 protease-4nhibitor complexes, 19 antigen-antibody complexes, and 32 other types of complexes. The horizontal arrow marks the range B = 1600 400A, which defines standard size interfaces. This range indudes 19 of the protease-inhibitor complexes, all but one of the 19 antigen-antibody complexes, and 15 of the others. Three small interfaces have B f 1150 A. Twenty complexes have large interfaces with areas in the range 2000-5000 A. ...

Three interfaces in the sample of 75 complexes of Lo Conte et al. (1999) have B 1150 A, just below the range 1200-2000 A dehning the standard size. The distinction may be spurious, due to experimental error or to missing contacts. In two of the crystal structures, one of the components is not the complete protein, and, therefore, the interface may be incomplete as in the HIV gp 120-CD4-Fab 27 crystal. These are the complex of a domain of Che A with Che Y [PDB code, laOo (Welch et al., 1998)], implicated in the two-component system of bacterial signal transduction, and the complex of a domain of the HIV capsid protein with cyclophilin [PDB code, lak4 (Gamble etal., 1996)]. 

Table 2.2 Standard Electrode Potentials at 25 °C and Their Isothermal Temperature Coefficients [12]—cont d...

Table 3.1-tt6 Compositional limits of HSLA steel grades according to ASTM standards [1.80], cont. 

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