Standardization of Allergen Provocation Tests

Allergen inhalation tests are primarily a research tool. For this reason, the principles of standardization have been developed to try and assure the best possible intraindividual reproducibility. The principles of standardization outlined below are based on both scientific and empirical concepts. Standardization encompasses technical aspects (aerosol generation, inhalation, measurement of response) and nontechnical or subject-related aspects, the latter designed to assure patient stability. 

Technical aspects of standardization of allergen provocation tests are the same as for other inhalation provocation tests (49,50). 

Two major techniques of aerosol generation and inhalation are used for allergen provocation tests. The first is a 2-minute period of tidal breathing from a continu- 

Marcel Dekker, Inc. 270 Madison Avenue, New York, New York 10016 

---