Standard Setting Non-Threshold Effects Carcinogenicity

In the hazard assessment process, described in detail in Chapter 4, aU effects observed are evaluated in terms of the type and severity (adverse or non-adverse), their dose-response relationship, and the relevance for humans of the effects observed in experimental animals. 

The approach of deriving a tolerable intake for non-threshold effects has been described and discussed extensively in the scientific hteramre. It is beyond the scope of this book to review all 

Toxicological Risk Assessments of Chemicals A Practical Guide 

The approach of deriving a tolerable intake for threshold effects is addressed in Chapter 5. 

The development of health-based guidance values, which are derived from the tolerable intake, is addressed in Chapter 9. 

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