Stable Lead Isotopic Tracers in Metabolic Studies

Stable Lead Isotopic Tracers in Metabolic Studies 

Stable lead isotope tracer methodologies have provided the most definitive measurements of lead metabolism in humans (Manton 1985 Rabinowitz et al. 1973, 1976, 1977 Smith et al. 1994). The inherent precision (sO.05% RSE) and sensitivity ( 1 ng sample Pb) of this technique allows the use of 

These advances in stable istopic tracer measurements are important because of the limitations in lead radiotracer measurements. Tracer studies of lead metabolism using radioisotopes ( Pb, Pb, and Pb) have been hindered by the relatively poor precision of the measurements, their relatively short ( Pb tin = 51.88 hr and Pb tm = 10.64 hr) or long ( Pb tin 22.3 yr) half-lives, and the relatively weak gamma energy of Pb. Additionally, concerns about the radiation hazard of these isotopes have severely restricted their utilization in many laboratory and clinical studies. 

---

B. Stable Lead Isotopic Tracers in Metabolic Studies... 

---