Stability constant gluconate

The major side effect of chelation therapy, particularly with EDTA, is hypocalcaemia, a condition caused by too rapid administration of the chelator. The result is a rapid drop in the ionized calcium in the blood plasma that causes muscle and abdominal cramps, convulsions, and even death. The condition is usually controlled by infusion of calcium gluconate, or prevented when the metal to be removed complexes with a much higher stability constant with EDTA than that of the Ca-EDTA, by administration as the Ca-EDTA complex. 

Other species is desirable first. To obtain such data, reliable stability constants of complexes and protonated ligands are required. Unfortunately, the data concerning Sn(II) complexes are few in number we were able to find only two articles containing quantitative characteristics of Sn(II) gluconate [94] and sulfate [95] complexes. The latter compounds can be also formed, because 0.5 M Na2S04 was used as a supporting electrolyte. Finally, the Sn(Il) hydrolysis processes should be also considered. 

The observed stability constants (.Kobs) for sensor 98 were 5140 with d-glucarate, 1450 with o-gluconate, 1300 with o-sorbitol, 62 with D-glucose and 46 with D-glucuronic acid in 50% methanol in 0.1 M aqueous HEPES bulfer at pH 7.4. 

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