SSBs

Another member of the FGF family, FGF-4, protects against radiation-iaduced ceU killing and enhanced the G2 arrest when overexpressed ia a human adrenal cortical carcinoma ceU line (196). This effect is again manifested as the appearance of a shoulder on the survival curve, although neither the control nor the transfected cells undergo radiation-iaduced apoptosis. No differences ia the yield or repair of either SSBs or DSBs have been observed. 

SSa Seebacb, D, M Missbacb, G Caldetari, and M Ebetle / Am Chem Soc. 112, 7625 i 1990 SSb Seebacb,D,G Caldetari,W L Meyet, A Merritt,andL Odetmann CVitmtn, 39, lS3i 19S5 ... 

The amplification of genetic information, i.e., the replication of parent DNA molecules, is achieved by means of an entire set of enzymes. The major players are a DNA-gyrase for unwinding of the double helix, proteins to separate the two antiparallel DNA strands at the replicational junction, single-stranded binding proteins (SSB) that prevent the... 

During the rephcation of DNA, there must be a separation of the two strands to allow each to serve as a template by hydrogen bonding its nucleotide bases to the incoming deoxynucleoside triphosphate. The separation of the DNA double hehx is promoted by SSBs, specific protein molecules that stabihze the single-stranded structure as the rephcation fork progresses. These stabi-... 

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