Squalene definition

In similarity to the biosynthesis of other cyclopropane-containing molecules, most mechanistic studies of squalene formation have been confined to chemical model systems and virtually no definitive experiments with the enzyme itself have been reported. 

Nicholas (1961) has shown, however, that suitably fortified minced rat brain preparations from 1-year-old animals will utilize 2-G -acetate and mevalonate to form labeled nonsaponifiable material. After incubation G -squalene and G -cholesterol were isolated from the preparations, by precipitation as digitonide and conversion to the dibromide, and thus a definite conversion by adult rat brain was established. As expected, liver was much more effective in synthesizing cholesterol, but both adult brain and liver slices utilized mevalonate more efiSciently than acetate. This therefore indicates an interesting difference in the cerebral metabolism of... 

Definition End prod, of the controlled hydrogenation of squalene Empirical CsoHeo Uses Emollient in cosmetics... 

Two atypical triterpenes were isolated from cultures of the species Euplotes vannus collected in Indonesia. These cyclical derivatives of squalene have an irregular carbon skeleton previously unknown in Nature. The relative percentages for varmusals A and B vary with the strain grown, and it has been shown that these derivatives are absent from Dunaliella salina, which is symbiotic with Euplotes vannus. The definitive structures of varmusals A and B were deduced from intense spectroscopic and synthetic researches (Nicolaou, Zhang, and Ortiz, 2009 Nicolaou, Ortiz, and Zhang, 2009 Nicolaou et al., 2010a, 2010b). 

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