Spray drying nanoparticles production

Much of the pivotal research into spray-drying was done by Masters in the 1950s, and his handbook remains one of the most useful references for those working in the field. The process has enjoyed enormous success, and has been scaled up for the production of milk products, coffee, vitamins, drugs such as acetominophen, and directly compressible excipients such as lactose and microcrystalline cellulose. Additionally, spray-drying has been used to convert nanoparticle dispersions into solid dosage forms. ... 

There are also other methods such as spray pyrolysis and electrospray pyrolysis besides the above method [26]. To prepare nanoparticles by spray pyrolysis, a starting solution is prepared by dissolving, usually, the metal salt of the product in the solvent. The droplets atomized from a starting solution are introduced to furnace. Drying, evaporation of solvent, diffusion of solute, precipitation, reaction of precursor, and surrounding gas, pyrolysis may occur inside the furnace before the formation of product. It is similar to spray drying except the type of precursor. For this, colloidal particles are typically used as precursors. Some products prepared by spray pyrolysis are listed in Table 34.1. 

FIGURE 20.8 A particle of dextran as a product of an atmospheric spray-freeze drying process. (From Leuenberger, HJ. Nanoparticle Res., 4, 111-119 (2002c).)... 

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