Spot-synthesis methodology

A novel concept for the synthesis of macrocyclic peptidomimetics 262, which incorporate heteroaromatic units, was reported (Scheme 39). This method involves sequential SNAr reactions of orthogonally protected amino groups of peptides and other linear oligomers on halogenated heterocycles such as 2,4,6-trichloro[l,3,5]triazines. The scope of this novel solid-phase approach was evaluated systematically by means of the SPOT-synthesis methodology on planar cellulose membranes <2000JC0361>. 

Aromax process, 1 665 25 171, 176 Aromizing-Aroformer process, 25 175 Arosolvan process, 3 606 P-Aroylacrylic acids, 15 486 2-Aroylbenzofurans, microwave-assisted synthesis of, 16 578 Array detector, 23 143 Array methodologies, 12 513-517 Arrays, large, 16 390 Array spotting/synthesis, in microarray fabrication, 16 385-387 Arrhenius equation, 10 85 14 622 ... 

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