Spontaneous pathology, animal disease models

Reports in the literature have proposed various animal models for preclinical studies of therapeutic radiopharmaceuticals in the laboratory, all of which pose serious limitations for investigations. In the present case, the efficacy of radiolabelled preparations was demonstrated in other models that more closely approximate the disease in humans. In this respect, it was envisaged that animals with spontaneous tumours could provide useful populations of pathological animal models for testing the new agents while also allowing their therapeutic efficacy and toxicity to be examined. 

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