Sponges peloruside

Peloruside A 14 (Scheme 6.1 Part 2) was isolated from a New Zealand Mycale hentschei marine sponge and initially showed activity against P388 murine leukaemia cells at 10 ng/mL.98 Peloruside s cytotoxicity profile and structural similarity to bryostatin led to the examination of protein kinase C (PKC) as a possible mode of action.242 This was determined to be incorrect and it was soon established that the remarkable activity of peloruside was through the stabilisation of microtubules at a site distinct from the taxoid site.243... 

Peloruside A (31), which is a 16-membered, highly oxidized macrolide from the sponge Mycale hentscheli, induces tubulin polymerization (2). 13-Deoxytedanolide (32) isolated from Japanese sponges of the genus Mycale shows promising antitumor activity. It inhibits protein synthesis by binding to a 70 S large subunit of eukaryotic ribosome (17). 

West, L. M., Northcote, P. T, and Battershill, C. N. (2000). Peloruside A A potent cytotoxic macrolide isolated from the New Zealand marine sponge Mycale sp. J. Org. Chem. 65,445-449. 

Miller, J.H., Singh, A.J., and Northcote, P.T. (2010) Microtubule-stabilizing drugs from marine sponges Focus on peloruside A and zampanolide. Mar. Drugs, 8,1059-1079. 

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