Troponin gene Splicing

Fig. 1.48. Differential splicing in muscle proteins, a) The troponin gene of rats possess 18 exons that encode 258 amino acids. Different subtypes of troponin are found in various types of muscle tissue.The exons 1-3 and 9-15 are found in aU subtypes, while the exons 4-8 appear in various combinations, allowing 32 possible combinations. Exon 16 or 17 are found in every subtype. Altogether, 64 different mRNAs can be formed from the troponin pre-mRNA. After Breitbart and Nadal-Grinard (1986). b) Tropomyosin is a muscle protein that can be alternatively spliced in different muscle tissue. Shown in the figure are the predominant subtypes for striated and smooth muscle. After Wieczorek et al., 1989.

Fig. 1.42 Differntial splicing in muscle proteins, a) The troponin gene of rats possess 18 exons that encode 258 amino acids. Different subtypes of troponin are found in various types of muscle tis-sue.The exons 1-3 and 9-15 are found in all subtypes, while the exons 4-8 appear in various combinations, allowing 32 possible combinations. Exon...

Fast skeletal troponin T gene and spliced mRNAs... 

Cooper, T.A. Ordahl, C.P. (1985). A single cardiac troponin T gene generates embryonic and adult isoforms via develop-mentally regulated alternate splicing. ]. Biol. Chem., 260, 11140-8. 

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