Spiro Ligands for Asymmetric Catalysis

State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 

Ligand Design in Metal Chemistry Reactivity and Catalysis, First Edition. Edited by Mark Stradiotto and Rylan J. Lundgren. 

1 -spirobiindane axially chiral C2-symmetric highly rigid 

The high rigidity is the key feature of the chiral spirobiindane ligands, which exhibited special advantages in many asymmetric reactions. One example is the Cu complex of chiral spiro bisoxazoline ligand (S, S,S)-23a (R=Ph). Zhu et al. [33] analyzed the X-ray structures of Cu(I)-(5, 5,5)-23a with various anions (PF, C10 , and BArp). All the complexes have an unexpected binuclear Cu structure, as shown 

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Spiro Ligands for Asymmetric Catalysis 85 4.3 Carbon-carbon bond-forming reactions... 

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