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Spiperone specific binding

Spiperone specific binding Striatum 6 weeks No change Lucchi et al.y 1981... [Pg.88]

Stable transfection in NIH-3T3 fibroblasts yielded specific binding with I-LSD, weak affinity for spiperone and high affinity for the mixed 5-HT2a/5-HT2c... [Pg.203]

The selective blockade of 5-HT, receptors by 300 nM 5-HT reduces the number of 3H-LSD binding sites to the Bmax of 5-HT2 receptors and, conversely, the occupancy of 5-HT2 receptors by 30 nM of spiperone allows the binding of 3H-LSD to sites qualitatively and quantitatively similar to the 5-HT, receptors (87). Because of this specific interaction of LSD with 5-HT receptors, the hallucinogen can be used as a probe for in vitro studies on such receptors in various... [Pg.80]

See other pages where Spiperone specific binding is mentioned: [Pg.96]    [Pg.96]    [Pg.144]    [Pg.111]    [Pg.54]    [Pg.130]    [Pg.142]    [Pg.159]    [Pg.412]    [Pg.80]    [Pg.210]    [Pg.98]    [Pg.39]    [Pg.110]    [Pg.554]    [Pg.22]    [Pg.27]    [Pg.45]    [Pg.105]    [Pg.39]    [Pg.301]    [Pg.156]   


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