Spindle solubility study

Much attention has been paid to taxol s unique mode of action, thanks to the pioneering efforts of Susan Horwitz [83, 84]. Mitotic spindle poisons , including colchicine, the vinca alkdoids, podophyllotoxin, and maytansine, bind to soluble tubulin and inhibit microtubule polymerization. Horwitz showed that, unlike any knovra antimitotic, taxol promotes microtubule assembly and stabilizes these structures to depolymerization by CaCl2 or cold [83, 84]. Typical of other ascomycetes and deuteromycetes tested, most of the fungi in our study do not appear to be compromised by taxol below 10 m [85]. Are yew-associated endophytes equally insensitive to spindle poisons like colchicine ... 

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