Spinal cord mossy fibers

The parallel fibers receive input from many sources via a complex series of mossy fibers and granule cells and influence the firing of the Punkinje cells. The output from the Purkinje cells is entirely inhibitory. It is transmitted via synapses in the cerebellar nuclei to neurons that lead back to the cerebral cortex, into the thalamus, and down the spinal cord.411 The pathway to the cortex completes an inhibitory feedback loop, of which there are many in the nervous system. For details see Llinas404 and Nicholls.149... 

Ruiz A, Fabian-Fine R, Scott R, Walker MC, Rusakov DA, Kullmann DM (2003) GABAA Receptors at hippocampal mossy fibers. Neuron 39 961 Rusakov DA, Saitow F, Lehre KP, Konishi S (2005) Modulation of presynaptic Ca2+ entry by AMPA receptors at individual GABAergic synapses in the cerebellum. J Neurosci 25 4930-40 Rustioni A (2005) Modulation of sensory input to the spinal cord by presynaptic ionotropic glutamate receptors. Arch Ital Biol 143 103-12... 

Other parts of the medial nucleus receive their mossy fiber collaterals from the lateral reticular nucleus (Kunzle, 1975 Russchen et al., 1976) and the spinal cord (Matsushita and Ikeda, 1970). The ventral, parvicellular part of the medial nucleus is located at the base of the lobules IX and X. 

Fig. 206. Plots of the distribution of mossy fibers on the dorsal (caudal) surface of lobule IV in the cat. A. Fibers from the central cervical nucleus (Matsushita and Tanami, 1987). B. Fibers from the medial vestibular nucleus (Matsushita and Wang, 1987). C. Fibers from the thoracic cord (Yaginuma and Matsushita, 1987). D. Fibers from the spinal border cells (Yaginuma and Matsushita, 1986). E. Fibers from the external cuneate nucleus (Gerrits, 1985). F. Fibers from the basal pontine nuclei (Gerrits, 1985). G. Localization of AChE in the molecular layer on the dorsal surface of lobule IV. Inset sagittal section of the cerebellum of the cat.

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