Sphingosine 1-phosphate receptor modulators

Sphingosine-1-phosphate receptor modulators FTY720 (Fingolimod)... [Pg.393]

Roberts, E., Rosen, H., Brown, S, Morales, M., Peng, X., and Poddutoori, R. (2009) Novel modulators of sphingosine phosphate receptors. WO2009151529A1. [Pg.326]

Sphingosine 1-Phosphate Type 1 Receptor Modulators Recent Advances and Therapeutic Potential... [Pg.245]

The major classes of immunosuppressive drugs employed in clinical practice to avoid tissue rejection include calcineurin inhibitors, target of rapamycin (TOR) inhibitors, sphingosine-1 -phosphate receptor (S1P-R) modulators, cytotoxic agents, glucocorticoids and monoclonal antibodies. These drugs need to be used on a lifelong basis and have major undesirable side effects. [Pg.88]

Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E. Baumruker T, Hies-tand P, Foster CA, Zolhnger M, Lynch KR (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277 21453 57... [Pg.41]

Brinkmann, V, Davis, MD, Heise, CE, Albert, R, Cottens, S, Hof, R, Bruns, C, Prieschl, E, Baumruker, T, Hiestand, P, Foster, CA, Zollinger, M and Lynch, KR (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. JBiol Chem, 111, 21453-21457. [Pg.100]

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