Sphingomyelin, sphingosine

Imaging/Labeling Applications Fibroblasts " galactosylceramide " glucose oxidase (GOx) horseradish peroxidase (HRP) laccase Upids lysozyme crystal nucleic acids paromomycin phosphatidylcholine " proteins sphingomyelin " sphingosines ... 

Among the products generated by the catabolism of sphingomyelin, sphingosine displayed exactly the same effects as sphingomyelinase they decrease both the cytosolic [Ca ] and Ca " influx induced by the CD3 mAb [6]. 

Sphingomyelins are the second major group of phospholipids. These compounds have sphingosine or a related dihydroxyamine as their backbone and are particularly abundant in brain and nerve tissue, where they are a major constituent of the coating around nerve fibers. 

Sphingomyelin (Section 27.3) A phospholipid that has sphingosine as its backbone. 

Sphingomyelin, 1066-1067 Sphingosine, structure of, 1067 Spin density surface, allylic radical, 342... 

Figure 12.12 Sphingomyelins. Sphingomyelins are esters of a ceramide and phospho-ryl choline. However, similar compounds are ceramide-1-phosphoryl ethanolamines and phosphono forms of sphingolipids. Ceramides W-acyl-sphingosines) are amides of a long chain di- or trihydroxy base containing 12 to 22 carbon atoms, of which sphingosine (4-sphingenine) is the commonest, and a long chain fatty acid whose acyl chain is shown by R1. This may contain up to 26 carbon atoms.

Ballou, L.R., Chao, C.P., Holness, M.A., Barker, S.C., and Raghow, R., 1992, Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J.Biol.Chem. 267 20044-20050. 

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