Specificity determining region

Kallunki, T., Su, B., Tsigelny, I. et al. 1994. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev 8 2996-3007. 

The structure of SH2 domains can be conveniendy divided into two functional regions that involved in coordination of the pTyr of the target and that which contacts the residues G-terminal to the pTyr (Fig. 2A). The pTyr binding cavity is found in the N-terminal half of the protein between the central p-sheet and helix oA, while the specificity determining region is found primarily in the C-terminal half of the protein between the central p-sheet and hehx aB (Fig. 2A). Each of these regions is described in detail below. 

Johansen, H.R., O.J. Rossland, and G. Becher. 1993. Congener specific determination of PCBs in crabs from a polluted fjord region. Chemosphere 27 1245-1252. 

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