Specific gene expression, effect

PC-SPES elucidation of effects of individual herbs of PC-SPES on proliferation and prostate specific gene expression in androgen-dependent LNCaP cells. Int J Oncol 2002 20(3) 583-588. 

Figure 6 Intrinsic and extrinsic factors modulating specific gene expression and its effect on tissue phenotype and function.

In addition to antiviral effects, interferons have antitumor effects. The mechanisms of the antitumor effects are not well understood, but are probably likewise related to stimulation of specific gene expression by STAT proteins. Interferon-a, produced by recombinant DNA technology, has been used to treat patients such as Arlyn Foma who have certain types of nodular lymphomas and patients, such as Mannie Weitzels, who have chronic myelogenous leukemia. 

Therapeutic effectiveness of synthetic double-stranded ODNs in modulating specific gene expression largely depends on several factors, including stability, specificity, and the efficient cellular and tissue uptake of ODN. One of the obstacles in decoy ODN strategy as a pharmaceutical drug concerns the stability of ODN in cells and blood. 

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