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Species Scaling Adjusting for Maximum Life Span Potential

Species Scaling Adjusting for Maximum Life Span Potential [Pg.128]

The consideration of clearance in units of volume per maximum life span potential, instead of the traditional volume per weight, provides an allometric relationship for drugs such as antipyrine and phenytoin [17]. Both of these dmgs are essentially low clearance compounds, cleared by P450 metabolism. Ultimately, the successful utility of such factors may be purely serendipitous as they simply exploit unique features of man as a species. [Pg.128]




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Life span

Scales for

Spans

Species Scaling

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