Spathelia sorbifolia

Another 4-methoxy-l-methyl-2-quinolone (10) was isolated from the roots of Spathelia sorbifolia L. (25). The constitution of the alkaloid was established by spectroscopy and confirmed by dimethylation of quinolone 9 with dimethyl sulfate in dimethylformamide. 

Structural work and chemistry is reported for active compounds from Annona densicoma, Cudrania cochinchinensi s, Desfontainia spinosa Pararistolochia flos-aviSy Podocarpus species, Psorospermum febrifuguniy and Spathelia sorbifolia. A number of these novel compounds exhibit sufficient activity to initiate studies of their mechanism of action and analog synthesis. 

Activity-directed fractionation of Spathelia sorbifolia has led to the isolation and structural elucidation of three new chromones, spatheliol (23), sorb ifoliol (24) and 6-(3 -methyl-3 -hydroxybut-1-enyl)-5-0-methyli so-spatheliachromen (25, ref. 78). 

Chan W R, Taylor D R, Willis C R 1967 The structure of sorbifolin, a chromone from Spathelia sorbifolia L. J Chem Soc (C) 2540-2542... 

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