Sucralfate Sparfloxacin

Zix JA, Geerdes-Fenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H. Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate. Antimicrob Agents Chemother 1997 41(8) 1668-72. 

Co-administration of sucralfate leads to a 44% reduction in the systemic availability of sparfloxacin (22). In eight healthy Japanese, the absorption of sparfloxacin (300 mg orally) was reduced when sucralfate (1.5 g orally) was administered concurrently or 2 hours after sparfloxacin, but not 4 hours after sparfloxacin (23). 

Kamberi M, Nakashima H, Ogawa K, Oda N, Nakano S. The effect of staggered dosing of sucralfate on oral bio-availability of sparfloxacin. Br J Clin Pharmacol 2000 49(2) 98-103. 

Sucralfate causes a marked reduction in the absorption of ciprofloxacin, enoxacin, gemifloxacin, lomefloxacin, moxifloxacin, ofloxacin, norfloxacin and sparfloxacin, but only a modest reduction in fleroxacin levels. 

In a study in 15 healthy subjects sucralfate 1 g four times daily reduced the maximum serum levels, the AUC and the relative bioavailability of sparfloxacin 400 mg daily by 39%, 47%, and 44%, respectively. In a study assessing staggered dosing of sucralfate 1.5 g on the pharmacokinetics of sparfloxacin 300 mg, the AUC was unaffected when sucralfate was given 4 hours after the quinolone, but was decreased by 34% when given 2 hours before, and 51% when given at the same time as sucralfate. ... 

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