Sparfloxacin Probenecid

PROBENECID QUINOLONES -CIPROFLOXACIN, LEVOFLOXACIN, NALIDIXIC ACID, NORFLOXACIN t ciprofloxacin, nalidixic acid and norfloxacin levels Uncertain Watch for t incidence of side-effects. Moxifloxacin, ofloxacin and sparfloxacin do not seem to interact and could be used as alternative therapy... 

Probenecid increases the serum ieveis and/or decreases the urinary excretion of cinoxacin, ciprofloxacin, clinafloxacin, enoxacin, fleroxacin, levofloxacin, nalidixic acid and norfloxacin. The ciinicai importance of these changes is uncertain, but is seems iikeiy they wiii oniy be important in the presence of other drugs that aiso affect renai excretion. Grepafloxacin, moxifloxacin, sparfloxacin, and probably ofloxacin, appear not to interact with probenecid. 

Probenecid 1.5 g did not significantly affect the clearance, the AUC or the half-life of sparfloxacin 200 mg in 6 healthy subjects. ... 

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