Space and the Linear Free Energy Formalism

Chemical Space and the Linear Free Energy Formalism 

QSAR analyses are based on the linear free energy relationships (LFER) formalism, where AGbj j, the standard free energy of binding, is directly pro- 

Numerically, AGbi d at 37 °C is approximately 6.0pKd (kj/mol), or 1.42pKj3 (kcal/mol). By comparing the binding free energy at various affinities, it can be observed that, even at extremely low M), AGbi d remains 

---