Sotalol Digoxin

Sotalol Sotalol Avoid Adenosine P-adrenergic blockers Calcium channel blockers Digoxin... 

Drugs that may be affected by telithromycin include cisapride, digoxin, ergot alkaloids, metoprolol, midazolam, pimozide, HMG-CoA reductase inhibitors, sotalol, and theophylline. 

Of 26 fetuses with hydrops fetalis and supraventricular tachycardias, 25 received transplacental drug therapy prenatal conversion occurred in 15 (82). Nine fetuses were converted to sinus rhythm using either flecainide (n = 7) or amiodarone (n = 2) as first-line therapy, while digoxin either alone or in association with sotalol failed to restore sinus rhythm in all cases. After first-line therapy, supraventricular tachycardia persisted in 10 fetuses, nine of whom received amiodarone alone or in association with digoxin as second-line therapy, and five of whom converted to sinus rhythm. Of 11 neonates who received amiodarone in utero, two developed raised thyroid stimulating hormone concentrations on postnatal days 3-4 they received thyroid hormone and had normal outcomes. 

Enalapril, paracetamol, sotalol, dipyrone, vancomycin, captopril, fluconazole, cefazolin, metoprolol, aspirin, ticlopidine, prednisolone, propranolol, digoxin, sildenafil, furosemide, dexamethasone, carvedilol, ketoprofen, nifedipine, terbinafine, acenocoumarol, spironolactone/urine HPLC DAD Column LiChroCART Purospher STAR, RP-18e (250 x 4 mm, 5 pm) Mobile phase MeOH ACN 0.05 % TFA in water (gradient elution) Detection DAD X = 200 50 nm Adjusted to pH 7.0, protein precipitation LOD 0.01-1.44 pg/mL LOQ 0.04-4.35 pg/mL [72]... 

This occurs in otherwise healthy individuals, who possess an anomalous (accessory) atrioventricular pathway they often experience attacks of paroxj mal AV re-entrant tachycardia or atrial fibrillation. Drugs that both suppress the initiating ectopic beats and delay conduction through the accessory pathway are used to prevent attacks e.g. flecainide, sotalol or amiodarone. Verapamil and digoxin may increase conduction through the anomalous pathway and should not be used. Electrical conversion may be needed to restore sinus rhythm when the ventricular rate is very rapid. Radiofrequency ablation of aberrant pathways will almost certainly provide a cure. 

The bradycardia produced by digoxin can be enhanced by beta-adrenoceptor antagonists. Neostigmine enhances vagal activity and can aggravate bradycardia (410). An apparent interaction between sotalol and thiazide-induced hypokalemia, resulting in torsade de pointes (411), has prompted the withdrawal of the combination formulation Sotazide. 

In a Prescription-Event Monitoring study in 3085 patients, mean age 65 years, there were 11 possible drug interactions. Nine involved beta-blockers, with eight reports of bradycardia and one of syncope. One patient developed palpitation and dyspnea while also taking digoxin and sotalol. 

Mscellaneous. A single dose of intravenous esmolol did not affect the pharmacokinetics of multiple-dose digoxin, except that a small increase was seen in the AUC of digoxin. The pharmacokinetics of multiple-dose digoxin have been shown to be unaffected by acebutolol, bevan-tolol 200 mg daily, bisoprolol 10 mg daily, nebivolol 10 mg daily, or sotalol 80 to 320 mg daily. 

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