Soriatane - Acitretin

Soriatane (Acitretin). Connectics. US Prescribing informatioi, July 2004. 

Unlike isotretinoin, acitretin (Soriatane) is not primarily sebosuppressive. Rather, it promotes normalization of dysregulated keratinocyte proliferative activity in the epidermis and is also antiinflammatory. Oral absorption is optimal when acitretin is taken with a fatty meal peak levels are reached approximately 3 hours after ingestion, while steady-state plasma levels are achieved after approximately 3 weeks of daily dosing. The mean terminal elimination half-life of the parent compound is 49 hours. However, when consumed with ethanol, acitretin may be transesterifled to form etretinate, a retinoid that is stored in adipose tissue, resulting in a much longer half-life (3-4 months or longer). 

Similar labeling language also in the labeling of AMNESTEEM (Isotretinoin) Mylan, May 2004 and SORIATANE (Connetics) (acitretin) capsules, March 2004. 

Acitretin (Soriatane), a metabolite of the aromatic retinoid etretinate, is quite effective in the treatment of psoriasis, especially pustular forms. It is given orally at a dosage of 25-50 mg/d. Adverse effects attributable to acitretin therapy are similar to those seen with isotretinoin and resemble hypervitaminosis A. Elevations in cholesterol and triglycerides may be noted with acitretin, and hepatotoxicity with liver enzyme elevations has been reported. Acitretin is more teratogenic than isotretinoin in the animal species studied to date, which is of special concern in view of the drug s prolonged elimination time (more than 3 months) after chronic administration. In cases where etretinate is formed by concomitant administration of acitretin and ethanol, etretinate may be found in plasma and subcutaneous fat for many years. 

Acitretin (Soriatane) Acyclovir (Zovirax) Alefacept (Amevive) Anthralin (Anthra-Derm) Amphotericin B (Amphocin) Bacitracin, Topical (Baciguent)... 

Adtretin. Acitretin (Soriatane) is a yellow to greenish-yellow powder. It is the active species of etretinate. After absorption, acitretin is extensively metabolized and also undergoes isomerization to its 3-tis isomer. Acitretin is less lipid soluble than etretinate and thus is eliminated fa.ster by the body. The elimination half-life is SO hours. 

Adtretin is a second-generation retinoid. Acitretin (Soriatane) is the major metabolite of etretinate, an aromatic retinoid that formerly was approved for psoriasis but withdrawn from the market because of its undesirable pharmacokinetics. Acitretin has an elimination half-Ufe of 2 to 3 days. 

Acitretin (Soriatane) Acyclovir (Zovirax) Alefacept (Amevive) Antliralin... 

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