Some Unclassified Experiments

SOME UNCLASSIFIED EXPERIMENTS It remains now to mention one or two experiments which are difficult to assign with certainty to any of the above categories, largely because certain experimental data are still lacking. 

There has been much discussion of this peculiar experiment, which may be summed up as follows  

If Eisenlolir and Meier are correct, the re.sult mast be cla.s.sed not as an asymmetric synthesis but as a second-order asymmetric transformation. The diastereoisomerides of II have no real existence in solution but as soon as crystallization sets in, the less soluble would be expected to separate out preferentially. There is, however, a complicating factor here which still makes it uncertain how this synthesis should be classified. Diastereoisomerides should differ significantly in all their phy.sical properties, and it is difficult to accept Eisenlohr and Meier s assertion that the diastereoiso-meric forms of II eliminate carbon dioxide at the same rate. It seems likely that the final optical activity is the resultant of two factors—a more or less one-sided asymmetric transformation, followed by optically selective breakdown of diastereoisomerides. 

Nothing further appears to have been published by these workers in support of this surprising claim, though an attempt by O Gorman (114) to 

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The next step Involved organization of Edgewood data and reports. Some of this material had to be declassified before use by the panels. Digests of the entire available literature, classified and unclassified, were prepared by consultant pharmacologists, and various documents were made available to the panels for their use in Investigating the possibility chat the Edgewood test experience resulted In persistent adverse effects. The panels met several times, beginning in June 1980. 

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