Some Comments on the Discrepancy

Modifications of DNA bases affect cell metabolism and may be related to carcinogenesis (Ames, 1989 Cerutti et al., 1989 Breimer, 1990,1991 Olinski etal., 1992 Lindahl, 1993), so it is important to understand this apparent discrepancy. What are the possible explanations First, HPLC may underestimate the real amount 

Commercial calf thymus DNA 0.5-1.0 159-318 640 Aruoma et al. (1989a, 1989b, 1991) 

Chromatin isolated from murine — 35-40 = 138 Dizdaroglu ef al. (1991b) 

---